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  Psychiatry & Neurology, Child Neurology

 
 
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Professor of Pediatrics in Radiology
Horace W. Goldsmith Foundation Professor of Pediatrics
Professor of Pediatrics
 
Weill Cornell \r\nPhysician
   

Kosofsky, Barry
 (212) 746-3278  (212) 746-8137

Peer Reviewed Articles
  1. Ide CF, Kosofsky BE, Hunt RK. Control of pattern duplication in the retinotectal system of xenopus. Dev Bio, 1979;69:337-360.
  2. Kosofsky BE, Molliver ME, Morrison JH, Foote JL. The serotonin and norepinephrine innervation of primary visual cortex in the Cynomolgus monkey (Macaca fascicularis). J Comp Neurol, 1984;230:168-78.
  3. Kosofsky BE, Molliver ME. The serotonergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse, 1987;1:153-68.
  4. Fritschy JM, Lyons WE, Mullen CA, Kosofsky BE, Molliver ME, Grzanna R. Distribution of locus coeruleus axons in the rat spinal cord: a combined anterograde transport and immunohistochemical study. Br Res, 1987;437:176-80.
  5. Gressens P, Kosofsky BE, Evrard P. Cocaine-induced disturbances of corticogenesis in the developing murine brain. Neurosci Lett, 1992;140:113-6.
  6. Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE. Differential expression of c-fos and zif/268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci, USA, 1992;89:4270-4.
  7. Hope B, Kosofsky BE, Hyman SE, Nestler EJ. Regulation of IEG expression and AP-1 binding by chronic cocaine in the rat nucleus accumbens. Proc Natl Acad Sci USA, 1992;89:5764-8.
  8. Leifer D, Krainc D, Yu YT, McDermott J, Breitbart RE, Heng J, Neve RL, Kosofsky BE, Nadal-Ginard B, Lipton SA. A novel MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci USA, 1993;90:1546-50.
  9. Kosofsky BE, Wilkins AS, Gressens P, Evrard P. Transplacental cocaine exposure: A mouse model demonstrating neuroanatomic and behavioral abnormalities. J Child Neurol, 1994;9:234-41.
  10. Kosofsky BE, Genova LM, Hyman SE. Postnatal age defines specificity of immediate early gene induction by cocaine in developing rat brain. J Comp Neurol, 1995;351:27-40.
  11. Kosofsky BE, Genova LM, Hyman SE. Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum. J Comp Neurol, 1995;351:41-50.
  12. Peterfreund RA, Kosofsky BE, Fink JS. Cellular localization of dopamine D2 receptor messenger RNA in the rat trigeminal ganglion. Anesth Analg, 1995;81:1181-5.
  13. Speliotes EK, Kowall NW, Shanti BF, Kosofsky B, Finklestein SP, Leifer D. Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia. Neuroscience, 1996;70:67-77.
  14. Mandeville JB, Marota JJA, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med, 1998;37:615-24.
  15. Wilkins AS, Genova LM, Posten W, Kosofsky BE. Transplacental cocaine exposure 1: a rodent model of drug-induced inattention. Neurotox Teratol, 1998;20:215-26.
  16. Wilkins AS, Jones K, Kosofsky BE. Transplacental cocaine exposure 2: the effects of cocaine dose and gestational timing. Neurotox Teratol, 1998;20:227-38.
  17. Wilkins AS, Marota JA, Tabit E, Kosofsky BE. Transplacental cocaine exposure 3: mechanisms underlying altered brain development. Neurotox Teratol, 1998;20:239-49.
  18. Marota JJA, Mandeville JB, Weisskoff RM, Moskowitz MA, Rosen BR, Kosofsky BE. Cocaine activation discriminates dopaminergic projections by temporal response: An fMRI study in rat. Neuroimage, 2000;11:13-23.
  19. Mandeville JB, Jenkins BG, Kosofsky BE, Moskowitz MA, Rosen BR, Marota, JJA. Regional Sensitivity and Coupling of BOLD and CBV changes during Stimulation of Rat Brain. Magn Reson Med, 2001;45:443-447.
  20. Planeta CS, Berliner J, Russ A, Kosofsky BE. The effect of prenatal cocaine exposure on the stress response of adult mice. Neurotox Research, 2001;3:53-64.
  21. Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, Aghajanian GK, Jaenisch R. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Mol Psychiatry, 2001;6(5):593-604.
  22. Pejchal T, Foley MA, Kosofsky BE, Waeber C. Fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTPgS autoradiography. Br J Pharmacol. 2002;135(5):1115-22.
  23. Rocha B, Mead A, Kosofsky BE. Increased vulnerability to self-administer cocaine in mice prenatally exposed to cocaine. Psychopharmacology, 2002:163: 221-229.
  24. Autret F, Dauger S, Renolleau S, Eng GV, Kosofsky BE, Gressens P, Gaultier C, Gallego J. Ventilatory control in newborn mice prenatally exposed to cocaine. Ped Pulmonary, 2002: 34:34-441.
  25. Redwine JM, Kosofsky BE, Jacobs RE, Games G, Reilly JF, Morrison JH, Young WG, Bloom FE. The dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci USA, 2003: 100:1381-1386.
  26. Crozatier C, Guerriero RM, Mathieu F, Giros B, Nosten-Bertrand M, Kosofsky, BE. Altered cocaine-induced behavioral sensitization in adult mice exposed to cocaine in utero. Developmental Brain Research. 2003:147; 97-105.
  27. Crandall JE, Hackett HE, Tobet SA, Kosofsky BE, Bhide PG Cocaine exposure decreases GABA neuron migration from the ganglionic eminence of the cerebral cortex in mice. Cereb Cortex, 2004:14;665-75.
  28. Husson I, Mesples BS, Medja F, Leroux P, Kosofsky BE, Gressens P. Methylphenidate and MK801, an NMDA receptor antagonist: shared biological properties. Neuroscience, 2004:125;163-170.
  29. Ren JQ, Malanga CJ, Tabit E, Kosofsky BE. Neuropathological consequences of prenatal cocaine exposure in the mouse. Int J Dev Neurosci, 2004:22;309-20.
  30. Rajadhyaksha A, Husson I, Satpute SS, Kuppenbender KD, Ren JQ, Guerriero RM, Standaert DG, Kosofsky BE. L-type Ca2+ channels mediate adaptation of extracellular signal-regulated kinase 1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment. J Neurosci, 2004;24;7464-76.
  31. Mandeville JB, Jenkins BG, Chen YC, Choi JK, Kim YR, Belen D, Liu C, Kosofsky BE, Marota JJ. Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magn Reson Med, 2004;52:1272-81.
  32. Guerriero RM, Rajadhyaksha A, Crozatier C, Giros B, Nosten-Bertrand M, Kosofsky BE. Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Dev Neurosci, 2005;27:235-248.
  33. Husson I, Rangon CM, Lelievre V, Bemelmans AP, Sachs P, Mallet J, Kosofsky BE, Gressens P. BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cereb Cortex, 2005;15:250-61.
  34. Sfaello I, Daire JL, Husson I, Kosofsky BE, Sebag G, Gressens P. Patterns of excitotoxin-induced brain lesions in the newborn rabbit: a neuropathological and MRI correlation. Dev Neurosci. 2005;27:160-168.
  35. Husson I, Rangon CM, Lelievre V, Bemelmans AP, Sachs P, Mallet J, Kosofsky BE, Gressens P. BDNF-Induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cereb Cortex, 2005;15:250-61.
  36. Bemelmans AP, Husson I, Jaquet M, Mallet J, Kosofsky BE, Gressens P. Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge. J Neurosci Res, 2006;83:50-60.
  37. Guerriero RM, Hayes MM, Dhaliwal SK, Ren JQ, Kosofsky BE. Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood. Biol Psych, 2006;60(11):1171-80.
  38. Giordano TP III, Satpute SS, Striessnig J, Kosofsky BE, Rajadhyaksha AM. Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels. J Neurochem, 2006;99(4):1197-206.
  39. Malanga CJ, Riday TT, Carlezon WA Jr., Kosofsky BE. Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective dopaminergic agonists in adult mice. Biol Psych, 2007 Jun 11.
  40. Malanga CJ, Pechal M, Kosofsky BE. Prenatal exposure to cocaine alters the development of conditioned place-preference. Pharmacol Biochem Behav, 2007;87(4):462-71.
  41. Worgall S, Kekatpure MV, Heier L, Ballon D, Dyke JP, Shungu D, Mao X, Kosofsky B, Kaplitt MG, Souweidane MM, Sondhi D, Hackett NR, Hollmann C, Crystal RG. Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology. 2007;69(6):521-35.
  42. Dyke JP, Voss HU, Sondhi D, Hackett NR, Worgall S, Heier LA, Kosofsky BE, Ulug AM, Shungu DC, Mao X, Crystal RG, Ballon D. Assessing Disease Severity in late infantile neuronal ceroid lipofuscinosis using quantitative MR diffusion-weighted imaging. Am J Neuroradiol. 2007;28(7):1232-6.
  43. Covington HE III, Tropea TF, Rajadhyaksha AM, Kosofsky BE, Miczek KA. NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking. Psychopharmacology (Berl) 2007.
  44. D'Arceuil H, Liu C, Levitt P, Thompson B, Kosofsky B, de Crespigny A. Three-Dimensional High-Resolution Diffusion Tensor Imaging and Tractography of the Developing Rabbit Brain. Dev Neurosci. 2007.

Clinical Research Articles

  1. Kuhn MJ, Mikulis DJ, Ayoub DH, Kosofsky BE, Davis KR, Taveras JM. Wallerian degeneration after cerebral infarction. Evaluation with sequential MR imaging. Radiology, 1989; 172:79-182.
  2. Marchuk DA, Gallione C, Prenger V, Kosofsky BE, Louis DN, Gusella JF, Davis LE, Morrison LA. A locus for cavernous angiomas maps to proximal 7q in two families. Genomics, 1995;28:311-314.
  3. Johnson EW, Green ED, Rich SS, Orr HT, Gil-Nagel A, Kurth JH, Zabramski JM, Marchuk DA, Weissenbach J, Clericuzio JCL, Davis1 LE, Hart BL, Gusella JF, Kosofsky BE, Louis DS, Morrison LA, Smith LM, Weber JL. Refined Localization of the Cerebral Cavernous Malformation Gene (CCM1) to a 4 cM Interval of Chromosome 7q Contained in a Well Defined YAC Contig. Genome Research, 1995;5:368-380.
  4. So GM, Kosofsky BE, Southern JF. Acute hydrocephalus following carbon monoxide poisoning. Ped Neurology, 1997;17:270-273.
  5. So GM, Herbert MR, Dooling EC, Buonanno, F, Kosofsky BE, Ebb D. Multifocal embolic strokes following cardiac surgery in a protein C-deficient child. J Child Neuro, 1998:13:629-31.
  6. Sahoo T, Johnson EW, Thomas JW, Jones Tl, Dokken CG, Lee-Lin S-Q, Kuehl PM, Touchman JW, Gallione CJ, Kosofsky B, Kurth JH, Louis DN, Mettler G, Morrison L, Gil-Nagel A, Rich SS, Zabramski JM, Boguski MS, Green ED, Marchuk DA. KRIT1, a Krev1/rapla binding protein, is mutated in cerebral cavernous malformations (CCM1). Hum Mol Genet, 1999;8:2325-2334.
  7. Walhovd KB, Moe V, Slinning K, Due-Tonnessen P, Bjornerud A, Dale AM, van der Kouwe A, Quinn BT, Kosofsky BE, Greve D, Fischl B. Volumetric cerebral characteristics of children exposed to opiates and other substances in utero. Neuroimage, 2007;36(4):1331-44.
  8. Worgall S, Kekatpure MV, Heier L, Ballon D, Dyke JP, Shungu D, Mao X, Kosofsky B, Kaplitt MG, Souweidane MM, Sondhi D, Hackett NR, Hollmann C, Crystal RG. Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology, 2007;69(6):521-35.
  9. Dyke JP, Voss HU, Sondhi D, Hackett NR, Worgall S, Heier LA, Kosofsky BE, Ulug AM, Shungu DC, Mao X, Crystal RG, Ballon D. Assessing Disease Severity in late infantile neuronal ceroid lipofuscinosis using quantitative MR diffusion-weighted imaging. Am J Neuroradiol, 2007;28(7):1232-6.


Books, Book Chapters and Reviews

  1. Cocaine: Effects on the Developing Brain (Harvey JA, Kosofsky BE, eds.) New York: NYAS Press, (1998).
    Prenatal Cocaine Exposure: Scientific Considerations and Policy Implications (Wenzel SL, Kosofsky BE, Harvey JA, Iguchi MY, Steinberg P, Watkins KE, Shaikh R, eds.) Santa Monica: RAND (2001).
  2. Kosofsky BE, Duitch DD, Dooling EC. Neurological Disorders. In: The Mass. General Hospital Handbook of Psychiatric Aspects of General Hospital Pediatrics, (Jellinek MS, Herzog DB, eds.) Year Book Medical Pub., (1990), 156-166.
  3. Kosofsky BE. The effect of cocaine on developing human brain. In: NIDA Research Monograph #114. Methodologic Issues in Controlled Studies on Effects of Prenatal Exposure to Drugs of Abuse (Kilbey MM, Asghar K, eds.). DHHS Pub. No. (ADM)91-1837. Washington D.C.: U.S. Govt. Print. Off., (1991), 128-143.
  4. Kosofsky BE, Hyman SE. The ontogeny of immediate early gene response to cocaine: A molecular analysis of the effects of cocaine on developing brain. In: NIDA Research Monograph #125. Activation of Immediate Early Genes by Drugs of Abuse (Grzanna RG, Brown RM, eds.). NIH Pub. No. 93-3504. Washington D.C.: U.S. Govt. Print. Off., (1993), 25-38.
  5. Hyman SE, Kosofsky BE, Nguyen TV, Cohen BM, Comb MJ. "Everything activates c-fos; how can it matter?". The complexity and biological significance of immediate early gene expression in substance abuse research. In: NIDA Research Monograph #125. Activation of Immediate Early Genes by Drugs of Abuse (Grzanna RG, Brown RM, eds.). NIH Pub. No. 93-3504. Washington D.C.: U.S. Govt. Print. Off., (1993), 161-171.
  6. Hyman SE, Cole RL, Konradi C, Kosofsky BE, Kobierski L, Cole D. Dopamine regulation of transcription factor - target interactions in rat striatum: regulation of proenkephalin, prodynorphin, and c-fos gene expression by transcription factor CREB. In: Molecular and Cellular Mechanisms of Neostriatal Function (Ariano MA, Surmeier DJ, eds.) Austin, TX: RG Landes, (1995), 129-141.
  7. Hyman SE, Cole RL, Konradi C, Kosofsky BE. Dopamine regulation of transcription factor - target interactions in rat striatum. Chemical Senses (1995) 20: 257-260.
  8. Wilkins AS, Kosofsky BE, Romano AG, Harvey JA.. Transplacental cocaine exposure: behavioral consequences. In: Prenatal Cocaine Exposure (Konkol RJ, Olsen GD, eds.) Boca Raton: CRC Press, (1996), 151-167.
  9. Raut CP, Stephen A, with Kosofsky B. Intrauterine effects of substance abuse. In: Source Book of Substance Abuse and Addiction (Friedman LS, Fleming NF, Roberts DH, Hyman SE, eds.) Baltimore: Williams & Wilkins, (1996), 269-287.
  10. Kosofsky BE. Cocaine-induced alterations in neuro-development. In: Seminars in Speech and Language (Mentis M, ed.) New York: Thieme Medical Publishers, (1998), 19, 109-121.
  11. Kosofsky BE, Wilkins AS. A mouse model of transplacental cocaine exposure. In: Cocaine: Effects on the Developing Brain (Harvey JA, Kosofsky BE, eds.) New York: NYAS Press, (1998), 846, 248-261.
  12. Malanga CJ III, Kosofsky BE. Mechanisms of action of drugs of abuse on the developing fetal brain. In: Prenatal Drug Exposure and Child Outcome (Lester, BM ed.) Clinics in Perinatology 26, (1999), 17-37.
  13. Kosofsky, BE. Effects of Alcohol and Cocaine on Brain Development. In: Neurobiologic Foundation of Mental Illness (Charney DS, Nestler EJ, Bunney BS, eds.) New York: Oxford University Press, (1999), 601-615.
  14. Trask CL, Kosofsky BE. Developmental Considerations of Neurotoxic Exposures. In: Clinical Neurobehavioral Toxicology (Albers JW, Berendt S, eds.) Neurologic Clinics 18, (2000), 541-561.
  15. Kosofsky BE, Hyman SE. No time for complacency: the fetal brain on drugs. Journal of Comparative Neurology 435, (2001), 259-62.
  16. Malanga CJ III, Kosofsky, BE. Effects of Drugs of Abuse on Brain Development. In: Neurobiologic Foundation of Mental Illness (Charney DS, Nestler EJ, Bunney BS, eds.) New York: Oxford University Press, Second Edition (2004), 720-739.
  17. Malanga CJ III, Kosofsky BE. Does drug abuse beget drug abuse? Behavioral analysis of addiction liability in animal models of prenatal drug exposure. Developmental Brain Research, 2003:147;47-57.
  18. Lester BM, Kosofsky, BE. Effects of Drugs of Abuse on Brain Development. In: Neurobiologic Foundation of Mental Illness (Charney DS, Nestler EJ, Bunney BS, eds.) New York: Oxford University Press, Third Edition (2007), in press.
   
   
 

Weill Cornell Physicians

Medical Practice(s)
Child Neurology
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Pediatric Neurology
 
Education
Ph.D., The Johns Hopkins University School of Medicine, 1985
M.D., Ph.D., The Johns Hopkins University School of Medicine, 1985
 
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